2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glutathione S-transferase

Glutathione S-transferase

Glutathione transferases; GSTs

Glutathione S-transferase

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Glutathione S-transferases (GSTs) are a diverse group of phase II drug metabolizing enzymes whose shared function is the conjugation of glutathione (GSH) to various electrophilic endo- and xenobiotics. GSTs have been implicated in the conjugation of endogenously produced oxidized metabolites including propenal, 4-hydroxynonenals, organic hydroperoxides, phospholipids, and fatty acid peroxides.

On the basis of subcellular localization, the GST enzymes are grouped into three different classes namely, membrane-bound microsomal, mitochondrial and cytoplasmic. The leading and most diverse group of GSTs are the cytosolic enzyme spresent in humans. These are known as phase II detoxification enzymes that comprise of at least 8 classes of isoenzymes: alpha (A), kappa (K), mu (M), omega (O), pi (P), sigma (S), theta (T), and zeta (Z). In addition, four different classes of this superfamily, called beta (β), delta(δ), phi (Φ) and tau (τ) are also present in bacteria, insects and plants.

GSTs have emerged as a promising therapeutic target because specific isozymes are overexpressed in a wide variety of tumors and may play a role in the etiology of other diseases, including neurodegenerative diseases, multiple sclerosis, and asthma.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136371
    Fluroxypyr-meptyl
    		Activator 99.81%
    Fluroxypyr-meptyl (Fluroxypyr-1-methylheptyl ester), a synthetical phytohormone, is used as herbicide agent.
    Fluroxypyr-meptyl
  • HY-N7227
    Anonaine
    		Inhibitor
    Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor.
    Anonaine
  • HY-136376
    Mefenpyr-diethyl
    		Activator 99.45%
    Mefenpyr-diethyl is an herbicide safener. Mefenpyr-diethyl enhances plant tolerance to herbicides by inducing the expression of antioxidant enzymes such as GST. Mefenpyr-diethyl protects crops against herbicide injury.
    Mefenpyr-diethyl
  • HY-137877
    7-Acetoxy-4-methylcoumarin
    		Inhibitor 98.65%
    7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition.
    7-Acetoxy-4-methylcoumarin
  • HY-N1282
    Seneciphylline
    		Activator 99.93%
    Seneciphylline is an orally effective hepatotoxic inducer. Seneciphylline is metabolized by CYP450 enzymes into active intermediates, which covalently bind to intracellular biomacromolecules such as proteins and DNA to form adducts, which in turn trigger a series of toxic reactions, such as inducing cell apoptosis and damaging mitochondrial function. Seneciphylline can be used in hepatotoxicity research[1][2].
    Seneciphylline
  • HY-160875
    GST-FH.1
    		Inhibitor
    GST-FH.1 is a GST-FH compound, a complex that produces frequent false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH) . GST-FH.4 inhibits glutathione S-transferase (GST) activity with an IC50 of 0.32 μM.
    GST-FH.1
  • HY-160926
    16-Oxocafestol
    		Inducer ≥98.0%
    16-Oxocafestol enhances levels of glutathione S-transferase (GST) and tissue sulfhydryl in liver and in small bowel mucosa.
    16-Oxocafestol
  • HY-145413
    BRD2889
    		Inhibitor
    BRD2889 is an analog of the alkaloid piperlongumine. BRD2889 is a robust modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH). BRD2889 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BRD2889
  • HY-161876
    GSTO1-IN-2
    		Inhibitor
    GSTO1-IN-2 (Compound B-9) is a dual covalent inhibitor of GSTO1/BTK with IC50 values of 441 nM and 6.2 nM respectively.
    GSTO1-IN-2
  • HY-108538
    Ethacrynic acid D5
    		Inhibitor
    Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.
    Ethacrynic acid D5
  • HY-121624
    Anthglutin
    		Inhibitor
    Anthglutin is a gamma-glutamyltransferase inhibitor isolated from Penicillium oxalicum cultures. The Ki values ??of Anthglutin for different enzymes are: porcine kidney enzyme 5.7 μM, human kidney enzyme 18.3 μM, human liver soluble enzyme 13.6 μM, and conjugated enzyme 10.2 μM. Anthglutin had no significant effect on intestinal absorption of methionine in rats.
    Anthglutin
  • HY-119524
    Clofibride
    Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo.
    Clofibride
  • HY-114585A
    Sperabillin A dihydrochloride
    		Inhibitor
    Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp.
    Sperabillin A dihydrochloride
  • HY-149419
    GST-IN-1
    		Inhibitor
    GST-IN-1 (compound 16) is a glutathione S-transferase (GST) inhibitor with IC50s of 1.55 μM (sjGST) and 2.02 μM (hGSTM2), respectively.
    GST-IN-1
  • HY-B1640S
    Ethacrynic acid-13C2,d5
    Ethacrynic acid-13C2,d5 is the deuterium and 13C labeled Ethacrynic acid.
    Ethacrynic acid-<sup>13</sup>C<sub>2</sub>,d<sub>5</sub>
  • HY-169058
    GSTP1-1 inhibitor 2
    		Inhibitor
    GSTP1-1 inhibitor 2 (Compound 5g) is an hGSTP1-1 (glutathione S-transferase P1-1) inhibitor with an IC50 value of 12.2 μM. GSTP1-1 inhibitor 2 exhibits significant cytotoxicity against DU-145, PC3, and MCF-7 cell lines, with CC50 values of 36.6 μM, 11.9 μM, and 17.4 μM, respectively. It can be used in cancer research.
    GSTP1-1 inhibitor 2
  • HY-N1282R
    Seneciphylline (Standard)
    		Activator
    Seneciphylline (Standard) is the analytical standard of Seneciphylline. This product is intended for research and analytical applications. Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities.
    Seneciphylline (Standard)
  • HY-160455
    GSTP1-1 inhibitor 1
    GSTP1-1 inhibitor 1 (compound 6b) is an irreversible, long-acting, glutathione S-transferase inhibitor with an IC50 of 21 μM targeting GSTP1-1 . GSTP1-1 is a key tumor suppressor target, and GSTP1-1 inhibitor 1 has potential anticancer activity.
    GSTP1-1 inhibitor 1
  • HY-119646
    Aviglycine
    		Inhibitor
    Aviglycine (ABG-3168 free base) is an inhibitor of ethylene biosynthesis with antibacterial activity. Aviglycine (ABG-3168 (free base)) application delays natural flowering in pineapple.
    Aviglycine
  • HY-115822
    α-Fluoromethylhistidine dihydrochloride
    		Inhibitor
    α-Fluoromethylhistidine dihydrochloride is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase, demonstrating significant potential in studying histidine metabolism and drug metabolism processes. α-Fluoromethylhistidine dihydrochloride offers an effective approach to inhibit enzymes involved in these metabolic pathways. α-Fluoromethylhistidine dihydrochloride has implications for drug development by revealing off-target effects that may influence physiological drug metabolism and elimination mechanisms.
    α-Fluoromethylhistidine dihydrochloride
Cat. No. Product Name / Synonyms Application Reactivity